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Details van artikel 107 van 140 gevonden artikelen
| Titel: |
Properties of grape seed proanthocyanidins and quercetin in human lymphocytes |
| Auteur: |
Stanković Miroslava Horvat Anica |
| Verschenen in: |
Archives of biological sciences |
| Paginering: | Jaargang 60 (2008) nr. 3 pagina's 367-377 |
| Jaar: |
2008 |
| Inhoud: |
This study addresses the in vitro protective effects of proanthocyanidins and quercetin on the frequency of micronuclei with reference to the antioxidant status of cultured human lymphocytes also subjected to 2 Gy of γ-radiation. Treatment of lymphocytes with proanthocyanidins induced a significant decrease in the frequency of micronuclei and reduction of malonyldialdehyde production, as well as increased catalase and glutathione S-transferase activity. Quercetin induces a higher incidence of micronuclei and production of malonyldialdehyde. The seven-fold increase of micronuclei frequency induced by a therapeutic dose of γ-radiation was decreased in the presence of proanthocyanidins. These results demonstrate that proanthocyanidins may be important in the prevention of ROS-induced oxidative lymphocyte damage by decreasing DNA damage, lowering membrane lipid peroxidation, and increasing the activity AOP enzymes, as well as by reducing the level of γ-radiation-induced DNA damage. Our results support the potential benefits of proanthocyanidins as efficient antioxidants and radioprotectors. |
| Uitgever: |
Srpsko biološko društvo, Institut za biološka istraživanja "Siniša Stanković", Biološki fakultet Univerziteta u Beogradu, Institut za primenu nuklearne energije u poljoprivredi, šumarstvu i veterinarstvu (provided by DOAJ) |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 107 van 140 gevonden artikelen
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