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Details for article 7 of 21 found articles
| Title: |
CYP2D6*4 polymorphisms and breast cancer risk |
| Author: |
D Surekha |
| Appeared in: |
Biology and medicine |
| Paging: | Volume 2 (2010) nr. 4 pages 49-55 |
| Year: |
2010 |
| Contents: |
CYP2D6 gene plays an important role in detoxification of many drugs and plays a crucial role in the metabolism oftamoxifen, used in endocrine therapy. In the present study, the heterozygous frequency IM (40.8%) was significantlyincreased in breast cancer patients when compared to controls. When the data on IM and PM were pooled,significant increase in the frequency of pooled genotype in disease group (42.4%) was observed as compared tocontrols (27.6%). The frequency of IM genotype was found to be increased in women with premenopausal breastcancer patients (43.5%) and patients with familial history of cancer (43.2%). Higher frequency of IM as well as pooledgenotypes PM+IM was found in cases with higher BMI and in patients occupied in agriculture (55.6%), patientspositive for estrogen receptor (47.8%), progesterone receptor (44.8%), HER2/neu (26.9%) and advanced stage. Ourresults suggested that the CYP2D6*4 polymorphism plays an important role in the breast cancer etiology and mighthelp in planning hormonal therapy where tamoxifen is used. |
| Publisher: |
E Business Navigators (provided by DOAJ) |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 7 of 21 found articles
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