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Details van artikel 3 van 12 gevonden artikelen
| Titel: |
Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach and analysis of urine and plasma samples |
| Auteur: |
Gilbert, J. Brereton, P. MacDonald, S. |
| Verschenen in: |
Food additives and contaminants. Pt. A, Chemistry, analysis, control, exposure & risk assessment |
| Paginering: | Jaargang 18 (2001) nr. 12 pagina's 1088-1093 |
| Jaar: |
2001-12-01 |
| Inhoud: |
The approach to assess exposure to ochratoxin A from the diet by the analysis of human plasma and urine samples has been developed. Composite duplicate diet samples from 50 individuals and corresponding plasma and urine samples were obtained over 30 days. Samples were analysed using sensitive methods capable of measuring ochratoxin A at 0.001ng g -1 in food, 0.1ng ml -1 in plasma and 0.01ng ml -1 in urine. Analysis of the foods indicated ochratoxin A levels contributing to an average intake in the range 0.26-3.54ng kg -1 bw day -1 over the 30 days. Ochratoxin A was found in all plasma samples and in 46 urine samples. The correlation between the plasma ochratoxin A levels and ochratoxin A consumption was not significant (95% confidence limit). However, a significant correlation was found between ochratoxin A consumption and the urine ochratoxin A concentration expressed as the total amount excreted. This new work offers the possibility of using ochratoxin A in urine as a simple and reliable biomarker to estimate exposure to this mycotoxin. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 12 gevonden artikelen
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