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| Titel: |
A Theoretical Model for Autism |
| Auteur: |
de caralho, Luis Alfred Vidal Ferreifa, Nive de Carvalho Fiszman, Adriana |
| Verschenen in: |
Computational & mathematical methods in medicine |
| Paginering: | Jaargang 3 (2001) nr. 4 pagina's 271-286 |
| Jaar: |
2001 |
| Inhoud: |
Autism is a mental disorder characterized by deficits in socialization, communication, and imagination. Along with the deficits, autistic children may show savant skills ("islets of ability") of unknown origin that puzzles their families and the psychologists. Comorbidity with epilepsy and mental retardation has brought the researchers' attention to neurobiological and cognitive theories of the syndrome. The present article proposes a neurobiological model for the autism based on the fundamental biological process of neuronal competition. A neural network capable of defining neural maps-synaptic projections preserving neighborhoods between two neural tissues-simulates the process of neurodevelopment. Experiments were performed reducing the level of neural growth factor released by the neurons, leading to ill-developed maps and suggesting the cause of the aberrant neurogenesis present in autism. The computer simulations hint that brain regions responsible for the formation of higher level representations are impaired in autistic patients. The lack of this integrated representation of the world would result in the peculiar cognitive deficits of socialization, communication, and imagination and could also explain some "islets of abilities", like excellent memory for raw data and stimuli discrimination. The neuronal model is based on plausible biological findings and on recently developed cognitive theories of autism. Close relations are established between the computational properties of the neural network model and the cognitive theory of autism denominated "weak central coherence", bringing some insight to the understanding of the disorder. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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