|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 6 van 23 gevonden artikelen
| Titel: |
FUROSEMIDE AND SPIRONOLACTONE REDUCE TRANSMIGRATION OF LEUKOCYTES THROUGH ENDOTHELIAL CELL MONOLAYERS |
| Auteur: |
Hofbauer, Roland Frass, Michael Pasching, Eva Gmeiner, Bernhard Kaye, Alan D. Kapiotis, Stylianos |
| Verschenen in: |
Journal of toxicology and environmental health. Part A |
| Paginering: | Jaargang 65 (2002) nr. 9 pagina's 685-693 |
| Jaar: |
2002-05-10 |
| Inhoud: |
Furosemide and spironolactone reduce transmigration of leukocytes through endothelial cell monolayers. Leukocytes play a tremendous role during inflammation. Leukocytes migrate from intravascular space into the tissue to attack microorganisms. Various agents are able to influence leukocyte recruitment. The influence of diuretics, such as furosemide and spironolactone, on inflammatory processes is not well known. The aim of our study was to examine the influence of furosemide and spironolactone on leukocyte migration through endothelial cell monolayers (ECM). Human umbilical vein endothelial cells were cultured on microporous membranes achieving a monolayer. Polymorphonuclear leukocytes (PMNL) were used in a currently described migration assay. PMNL and/or ECM were pretreated with furosemide and spironolactone using therapeutic, as well as higher and lower, concentrations. Furosemide (76 ±7.2%) and spironolactone (70 ±7.7%) were able to inhibit PMNL migration through ECM significantly, when both cell types were treated simulating the situation after an iv injection. Furosemide and spironolactone were identified as potent inhibitors of leukocyte migration through ECM. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 6 van 23 gevonden artikelen
| << vorige | volgende >> |