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| Titel: |
URINARY 8-HYDROXYDEOXYGUANOSINE AND SISTER CHROMATID EXCHANGES IN PATIENTS WITH TOTAL HIP REPLACEMENTS |
| Auteur: |
Pilger, Alexander Schaffer, Andreas Rudiger, Hugo W. Osterode, Wolf |
| Verschenen in: |
Journal of toxicology and environmental health. Part A |
| Paginering: | Jaargang 65 (2002) nr. 9 pagina's 655-664 |
| Jaar: |
2002-05-10 |
| Inhoud: |
Ion release from metal implants has been suspected to increase the risk of genotoxic effects in patients wearing orthopedic metal devices. In this study we used urinary 8-hydroxydeoxyguanosine (8-OHdG) as marker of oxidative DNA damage and the frequency of sister chromatid exchanges in lymphocytes to test a possible relationship between the concentrations of chromium or cobalt and the induction of cytogenetic modifications in 46 patients with total hip replacements. A broad range of individual levels of metals has been observed in these patients: chromium in blood, 1.59-14.11 µg/L; chromium in urine, 0.79-93.80 µg/24 h; cobalt in blood, 0.77-37.80 µg/L; cobalt in urine, 2.59-166.94 µg/24 h. By linear regression analysis, no significant correlation between urinary 8-OHdG or sister chromatid exchange (SCE) and the concentrations of metals was found. However, cobalt in blood as well as 8-OHdG in urine were higher in patients with implants 3-4 yr old as compared to patients with implants 1-2 yr old. Smoking significantly increased the frequency of SCE. Our data do not indicate a dependence of 8-OHdG in urine or SCE on the levels of chromium or cobalt in patients with total hip replacements. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 23 van 23 gevonden artikelen
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