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| Titel: |
Oxidative Stress-Related Markers and Langerhans Cells in a Hairless Rat Model Exposed to UV Radiation |
| Auteur: |
Mulero, Miquel Romeu, Marta Giralt, Montserrat Folch, Jaume Nogues, Maria Rosa Fortuno, Angels Sureda, Francesc Xavier Linares, Victoria Cabre, Maria Paternain, Jose Luis Mallol, Jordi |
| Verschenen in: |
Journal of toxicology and environmental health. Part A |
| Paginering: | Jaargang 69 (2006) nr. 14 pagina's 1371-1385 |
| Jaar: |
2006-08-01 |
| Inhoud: |
Biomarkers related to the oxidative stress in blood and epidermis and the number of Langerhans cells were determined in hairless rats after acute irradiation with 1.54, 1.93, or 2.41 J/cm2 of ultraviolet (UV) light and chronic exposure to 13 suberythemal UV doses of 1.1 J/cm2 for 2 mo. After acute UV irradiation, in epidermis, the thiobarbituric acid-reactive substances (TBARS) content increased at the highest UV dose, whereas the activities of glutathione S-transferase and catalase rose and the oxidized glutathione (GSSG) content diminished at all UV doses. In erythrocytes, glutathione S-transferase activity increased at the two lowest UV doses, glutathione peroxidase activity rose at all UV doses, and catalase activity increased after the highest UV dose. In plasma, the TBARS content and the reduced glutathione (GSH)/GSSG ratio increased at the highest UV dose; the number of Langerhans cells decreased at all UV doses. Linear Pearson correlation analysis revealed many relationships between different biomarkers, and multiple linear regression analysis indicated that the number of Langerhans cells was predicted by epidermal GSSG and catalase (R2 = .64) and by erythrocytic glutathione peroxidase and GSSG (R2 = .72). After suberythemal UV radiation, in epidermis, the GST activity and the content of GSH and GSSG increased; in erythrocytes, the GST activity decreased and the GSH/GSSG ratio increased. Thus, the hairless rat appears to be a useful model for studying the oxidative stress-related mechanisms after UV radiation, which are involved in the loss of the immune capacity mediated by Langerhans cells, even at suberythemal doses. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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