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| Titel: |
The Expanding Role of Predictive Toxicology: An Update on the (Q)SAR Models for Mutagens and Carcinogens |
| Auteur: |
Benigni, Romualdo Netzeva, Tatiana I. Benfenati, Emilio Bossa, Cecilia Franke, Rainer Helma, Christoph Hulzebos, Etje Marchant, Carol Richard, Ann Woo, Yin-Tak Yang, Chihae |
| Verschenen in: |
Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews |
| Paginering: | Jaargang 25 (2007) nr. 1 pagina's 53-97 |
| Jaar: |
2007-01 |
| Inhoud: |
Different regulatory schemes worldwide, and in particular, the preparation for the new REACH (Registration, Evaluation and Authorization of CHemicals) legislation in Europe, increase the reliance on estimation methods for predicting potential chemical hazard. To meet the increased expectations, the availability of valid (Q)SARs becomes a critical issue, especially for endpoints that have complex mechanisms of action, are time-and cost-consuming, and require a large number of animals to test. Here, findings from the survey on (Q)SARs for mutagenicity and carcinogenicity, initiated by the European Chemicals Bureau (ECB) and carried out by the Istituto Superiore di Sanita' are summarized, key aspects are discussed, and a broader view towards future needs and perspectives is given. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 91 van 100 gevonden artikelen
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