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| Titel: |
Use of liposome encapsulated sodium- 2,3-dimercapto-propane sulfonate (DMPS) in the treatment of mice loaded with cadmium |
| Auteur: |
Behari, Jai Raj Gupta, Sanjay Srivastava, Sadhna Srivastava, R. C. |
| Verschenen in: |
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering |
| Paginering: | Jaargang 25 (1990) nr. 6 pagina's 597-610 |
| Jaar: |
1990-08 |
| Inhoud: |
Sodium-2, 3-dimercaptopropane sulfonate (DMPS) is a potent thiol chelating drug used against heavy metal intoxication. With a view to enhance its efficacy at low dose DMPS was encapsulated in liposomes made up of equimolar egg phosphotidylcholine and cholesterol and then administered to mice loaded with cadmium. Both the free as well as liposomal drug enhanced urinary excretion of cadmium. While fecal excretion of cadmium was enhanced only by liposomal drug, liposomal DMPS was effective in mobilizing more cadmium from blood, liver, kidney and spleen by day 3 of treatment, Liposomal DMPS was also able to decorporate some cadmium from cadmium binding proteins with low molecular weight corresponding to metallothionein. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 11 van 11 gevonden artikelen
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