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Details for article 4 of 7 found articles
| Title: |
Comparison of steroidal synthetic agents cytolytic toward Florida red tide organism (Gymnodinium breve, Ptychodiscus brevis) |
| Author: |
Martin, Dean F. Krumrei, Thomas N. Moon, Ralph E. |
| Appeared in: |
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering |
| Paging: | Volume 15 (1980) nr. 1 pages 37-44 |
| Year: |
1980 |
| Contents: |
Analysis of a natural control agent for the red tide organism (G. breve, P. brevis) indicated the presence of sterols as an active, or adventitious component of a cytolytic mixture elaborated by the cyanobacterium Gomphosphaeria aponina Kutzing. Comparisons of several plant sterols showed cholesta-5,7-dien-3ss-ol (7-dehydrocholesterol) was cytolytically active toward G. breve. Derivatives of cholesta-5,7-dien-3ss-ol and cholest-5-en-3ss-ol (7-dehydrocholesterol and cholesterol) were prepared to enhance water solubility. Derivatives of the type ROCO(CH2)4CO(OCH2CH2)nOH varied markedly in cytolytic activity with G. breve as the bioassay organism. The derivative of cholest-5en-3ss-ol (cholesterol) (n = 12.5) showed no discernable cytolytic activity up to 20 ppm, but the cholesta-5,7-dien-3ss-ol (7-dehydrocholesterol) derivatives (n = 22, 12.5, or 4) were cytolytic at about 5 ppm and had a dose-dependent response. Implications of the observations are considered. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 4 of 7 found articles
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