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| Titel: |
A NEW FORMULATION FOR BLOOD SUBSTITUTES |
| Auteur: |
Cecutti, C. Novelli, A. Rico, I. Lattes, A. |
| Verschenen in: |
Journal of dispersion science and technology |
| Paginering: | Jaargang 11 (1990) nr. 2 pagina's 115-123 |
| Jaar: |
1990-04-01 |
| Inhoud: |
The synthesis of a novel microemulsion system composed of a fluorinated oil C8F17-CH2-CH-CH-C4H9 with a biocompatible hy-drogenated surfactant, Montanox 80, is described. Investigation of the solubility of oxygen in these microe-mulsions showed that they absorbed more oxygen than Fluosol-DA, currently used as an oxygen transporter in biological systems. Oxygen absorption was comparable to that of blood. Light scattering studies showed that these systems are composed of small-sized aggregates which should, in principle, be compatible with blood. The toxicity of the oil C8F17-CH2-CH = CH-C4H9 was tested after intraperitoneal injection in rats. No toxic effects were observed at doses up to 5 g/kg This study opens new perspectives for the development of oxygen-transporting compounds for biomedical applications. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 10 van 189 gevonden artikelen
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