Li, S. An, T. -Y. Li, J. Shen, Q. Lou, F. -C. Hu, L. -H.
Verschenen in:
Journal of Asian natural products research
Paginering:
Jaargang 8 (2006) nr. 3 pagina's 281-286
Jaar:
2006-04
Inhoud:
A new lignan glycoside, named 1,5-dihydroxypinoresinol-4'-O-β-d-glucopyranoside (1), has been isolated from the EtOH extract of the roots of Saussurea lappa, together with twenty known compounds: (+)-1-hydroxypinoresinol-1-O-β-d-glucopyranoside (2), fraxiresinol-4'-O-β-d-glucopyranoside (3), ( - )-olivil-4''-O-β-d-glucopyranoside (4), 4-allyl-2,6-dimethoxybenzene-1-O-β-d-glucopyranoside, syringin, costunolide-15-O-β-d-glucopyranoside, chlorogenic acid, aloe-emodin-8-O-β-d-glucopyranoside (5), rhein-8-O-β-d-glucopyranoside (6), chrysophanol (7), emodin, dehydrocostus lactone, costunolide, β-costic acid, reynosin, arbusculin A, α-cyclocostunolide, β-cyclocostunolide, santamarine and magnolialide. Three anthraquinones (5-7) showed moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.