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Details van artikel 9 van 17 gevonden artikelen
| Titel: |
Preparation and antitussive, expectorant, and antiasthmatic activities of verticinone's derivatives |
| Auteur: |
Zhang, Yong-Hui Ruan, Han-Li Pi, Hui-Fang Wu, Ji-Zhou Sun, Han-Dong Fujita, Tetsuro |
| Verschenen in: |
Journal of Asian natural products research |
| Paginering: | Jaargang 10 (2008) nr. 7 pagina's 627-633 |
| Jaar: |
2008-07 |
| Inhoud: |
To prepare verticinone derivatives with significant antitussive, expectorant, and antiasthmatic activities, the compounds 3β-acetylverticinone (1), 3-ketoverticinone (2), 3β-benzoylverticinone (3), 3β-propionylverticinone (4), 3β-butyrylverticinone (5), and 3β-butoxycarbonylverticinone (6) have been prepared. All of these are new compounds. Among them, 1-6 exhibited potent antitussive and expectorant activities; 1 and 3-6 displayed various antiasthmatic activities. The antitussive activity of 1-6, the expectorant activity of 1-2 and 4-6, and the antiasthmatic activity of 1 are higher than those of verticinone. The results demonstrated that 1 had dominant biological activities, suggesting that it would be a potential antitussive, expectorant, and antiasthmatic agent. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 9 van 17 gevonden artikelen
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