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Details van artikel 9 van 17 gevonden artikelen
| Titel: |
Scutellarin induced Ca2+ release and blocked KCl-induced Ca2+ influx in smooth muscle cells isolated from rat thoracic artery |
| Auteur: |
Zhu, Bang-Hao Ma, Li Pan, Xue-Diao Huang, Yu-Ling Liu, Jie |
| Verschenen in: |
Journal of Asian natural products research |
| Paginering: | Jaargang 10 (2008) nr. 6 pagina's 583-589 |
| Jaar: |
2008-06 |
| Inhoud: |
This study was designed to investigate the effect of scutellarin (1) on the modulation of intracellular Ca2+ concentration in thoracic smooth muscle cells of rat. Single smooth muscle cells were obtained enzymatically. Fluo-3 AM was used to determine the alteration of intracellular-free Ca2+ ([Ca2+ ]i) and the changes in fluorescence intensity under different agonists were recorded. Compound 1 induced Ca2+ transients in the medium with and/or without Ca2+ . In the Ca2+ -free medium, after pretreatment of 1, thapsigargin failed to cause the elevation of [Ca2+ ]i. However, 1 still caused the elevation of [Ca2+ ]i after pretreatment of thapsigargin. The infusion of 1 blocked KCl-induced Ca2+ entry and this effect was hardly reversible. The results of present study suggested that 1 increased [Ca2+ ]i by blocking sarcoplasmic reticulum Ca2+ /ATPase and blocked voltage-dependent Ca2+ channels in smooth muscle cells of the rat thoracic aortic artery. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 9 van 17 gevonden artikelen
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