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| Titel: |
Acute neurovascular unit protective action of pinocembrin against permanent cerebral ischemia in rats |
| Auteur: |
Gao, Mei Liu, Rui Zhu, Shen-Yin Du, Guan-Hua |
| Verschenen in: |
Journal of Asian natural products research |
| Paginering: | Jaargang 10 (2008) nr. 6 pagina's 551-558 |
| Jaar: |
2008-06 |
| Inhoud: |
Acute vascular- and neuroprotective effects of pinocembrin (1) were evaluated in a rat model of focal cerebral ischemia. Focal cerebral ischemia was induced by the middle cerebral artery occlusion (MCAO) for 24 h. 5,7-Dihydroxyflavanone (compound 1; at 3, 10, or 30 mg/kg), intravenously injected at 0, 8, and 16 h after MCAO, reduced the cerebral infarct volumes by 47, 39, and 37%, respectively, as visualized by 2,3,5-triphenyltetrazolium chloride staining (P < 0.01). Treatment with 1 also reduced brain swelling and improved behavioral deficits significantly (P < 0.01 and 0.05, respectively). To evaluate the effect of 1 on blood-brain barrier (BBB) disruption, mixture of Evans Blue (EB) and sodium fluorescein (NF) was intravenously injected immediately after MCAO. Global NF/EB uptake and fluorescence imaging of local BBB disruption were measured. Treatment with compound 1 reduced the leakage of both dyes, manifesting a preventive action in BBB integrity. This is the first time to demonstrate that 1 has acute neurovascular protective action against permanent focal cerebral ischemia. The mechanism of neurovascular protective action of 1 is under investigation. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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