|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 2 van 13 gevonden artikelen
| Titel: |
A triterpene saponin from Tribulus terrestris attenuates apoptosis in cardiocyte via activating PKC signalling transduction pathway |
| Auteur: |
Sun, WEI Li, HONG Yang, SHI-JIE |
| Verschenen in: |
Journal of Asian natural products research |
| Paginering: | Jaargang 10 (2008) nr. 1 pagina's 39-48 |
| Jaar: |
2008-01 |
| Inhoud: |
The present study was conducted to examine the role of hecogenin-3-O-β-d-glucopyranosyl(1 → 4)-β-d-galactopyranoside (1), which is a triterpene saponin of Tribulus terrestris in cardiocytes during chemical hypoxia-ischaemia in vitro. Neonatal rat ventricular myocytes were isolated by collagenase digestion and treated with NaCN for 12 h. Cell apoptosis was defined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) and flow cytometry. [Ca2 + ] was measured by confocal microscopy. There was a marked increase in the expression of the anti-apoptotic protein, Bcl-2, by NaCN. This change was increased by the saponin 1. PKCε protein contents were increased in the cardiocyte membrane fraction in response to NaCN. PKCε activation was augmented by the saponin 1. Inhibition of PKCε with inhibitory peptide prevented Bcl-2 expression. Moreover, the saponin attenuated the apoptosis in cardiocyte in response to NaCN. It is therefore suggested that the saponin 1 may play a role in cardiocyte survival via PKCε and Bcl-2. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 13 gevonden artikelen
| << vorige | volgende >> |