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Details van artikel 84 van 133 gevonden artikelen
| Titel: |
Preparation and evaluation of new brominated paclitaxel analogues |
| Auteur: |
Jiang, Yi Lin, Hai-Xia Li, Ming Wu, Bei-Li Chen, Jian-Min |
| Verschenen in: |
Journal of Asian natural products research |
| Paginering: | Jaargang 7 (2005) nr. 3 pagina's 231-236 |
| Jaar: |
2005-06 |
| Inhoud: |
Two diastereomers of 2'',3''-dibromo-7-epi-10-deacetylcephalomannine, 4 and 5, have been synthesized, purified and identified for evaluation as antitumour drugs. The cytotoxicity of the two diastereomers, assessed in cell culture against MCF-7 breast cancer, A549 lung cancer and A2780 ovarian cancer, was slightly stronger than that of paclitaxel. The cytotoxicity of 5 outweighs that of 4. In the light of the difference in cytotoxicity between the two diastereomers, we can assume that the differing configurations of C-2'' and C-3'' of the two diastereomers may result in different bioactive conformations in solution and, consequently, different biologically relevant conformations for binding to tubulin/microtubules — a matter we are studying further. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 84 van 133 gevonden artikelen
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