Terminoside A, a new triterpene glycoside from the bark of Terminalia arjuna inhibits nitric oxide production in murine macrophages
Titel:
Terminoside A, a new triterpene glycoside from the bark of Terminalia arjuna inhibits nitric oxide production in murine macrophages
Auteur:
Ali, Asif Kaur, Gurpreet Hamid, Hinna Abdullah, Tarique Ali, Mohammed Niwa, M. Alam, M. S.
Verschenen in:
Journal of Asian natural products research
Paginering:
Jaargang 5 (2003) nr. 2 pagina's 137-142
Jaar:
2003-06
Inhoud:
Terminoside A (1), a new oleanane-type triterpene was isolated from the acetone fraction of the ethanolic extract of stem bark of Terminalia arjuna. The structure was established as olean-1α,3β,22β-triol-12-en-28-oic acid-3β-d-glucopyranoside. On the basis of spectral data and chemical reactions, terminoside A, potently inhibited nitric oxide (NO) production and decreased inducible nitric oxide synthase (iNOS) levels in lipopolysaccharide-stimulated macrophages.