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Details van artikel 19 van 29 gevonden artikelen
| Titel: |
The effect of salidroside on cell damage induced by glutamate and intracellular free calcium in PC12 cells |
| Auteur: |
CAO, Li-Li DU, Guan-Hua WANG, Min-Wei |
| Verschenen in: |
Journal of Asian natural products research |
| Paginering: | Jaargang 8 (2006) nr. 1-2 pagina's 159-165 |
| Jaar: |
2006-01 |
| Inhoud: |
Salidroside (Sald), was extracted from Rhodiola rosea L, a traditional Chinese medicine which has been used for long time for anti-aging, anti-cancer and anti-oxidative stress etc. In present experiment, salidroside could protect the PC12 cell against injuries caused by exposure of PC12 cells to 2 mmol/L glutamate for 15 min followed by incubation with serum-free medium for 24 h, which resembled the excitotoxin in vivo system. Furthermore, saldroside could decrease the [Ca2+]i of PC12 cells in Mg2+-free Hanks' solution and D-Hanks' solution but there was no effect on basal [Ca2+]i in Hanks' solution. The studies also indicated that salidroside inhibited the increases of [Ca2+]i induced by KCl and glutamate. In conclusion, salidroside may protect PC12 cell against glutamate excitotoxic damage through suppressing the excessive entry of Ca2+ and the release of the calcium stores. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 19 van 29 gevonden artikelen
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