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  Robust filtering for gene expression time series data with variance constraints
 
 
Titel: Robust filtering for gene expression time series data with variance constraints
Auteur: Wei, Guoliang
Wang, Zidong
Shu, Huisheng
Fraser, Karl
Liu, Xiaohui
Verschenen in: International journal of computer mathematics
Paginering: Jaargang 84 (2007) nr. 5 pagina's 619-633
Jaar: 2007-05
Inhoud: In this paper, an uncertain discrete-time stochastic system is employed to represent a model for gene regulatory networks from time series data. A robust variance-constrained filtering problem is investigated for a gene expression model with stochastic disturbances and norm-bounded parameter uncertainties, where the stochastic perturbation is in the form of a scalar Gaussian white noise with constant variance and the parameter uncertainties enter both the system matrix and the output matrix. The purpose of the addressed robust filtering problem is to design a linear filter such that, for the admissible bounded uncertainties, the filtering error system is Schur stable and the individual error variance is less than a prespecified upper bound. By using the linear matrix inequality (LMI) technique, sufficient conditions are first derived for ensuring the desired filtering performance for the gene expression model. Then the filter gain is characterized in terms of the solution to a set of LMIs, which can easily be solved by using available software packages. A simulation example is exploited for a gene expression model in order to demonstrate the effectiveness of the proposed design procedures.
Uitgever: Taylor & Francis
Bronbestand: Elektronische Wetenschappelijke Tijdschriften
 
 

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