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| Titel: |
The Importance of Human Data in the Establishment of Occupational Exposure Limits |
| Auteur: |
Sargent, Edward V. Naumann, Bruce D. Dolan, David G. Faria, Ellen C. Schulman, Lisa |
| Verschenen in: |
Human and ecological risk assessment |
| Paginering: | Jaargang 8 (2002) nr. 4 pagina's 805-822 |
| Jaar: |
2002-10-01 |
| Inhoud: |
The use of animal vs. human data for the purposes of establishing human risk was examined for four pharmaceutical compounds: acetylsalicylic acid, cyclophosphamide, indomethacin and clofibric acid. Literature searches were conducted to identify preclinical and clinical data useful for the derivation of acceptable daily intakes (ADIs) from which a number of risk values including occupational exposure limits (OELs) could be calculated. OELs were calculated using human data and then again using animal data exclusively. For two compounds, ASA and clofibric acid use of animal data alone led to higher OELs (not health protective), while for indomethacin and cyclophosphamide use of animal data resulted in the same or lower OELs based on human data alone. In each case arguments were made for why the use of human data was preferred. The results of the analysis support a basic principle of risk assessment that all available data be considered |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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