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Details van artikel 101 van 222 gevonden artikelen
| Titel: |
Haber's Rule: The Search for Quantitative Relationships in Toxicology |
| Auteur: |
Bunce, Nigel J. Remillard, Rene B. J. |
| Verschenen in: |
Human and ecological risk assessment |
| Paginering: | Jaargang 9 (2003) nr. 4 pagina's 973-985 |
| Jaar: |
2003-06-01 |
| Inhoud: |
Dose (or concentration) and time of exposure are both important in determining the intensity of response to a toxic agent. For a given response intensity, Haber's Rule (c×t=K) has been proposed as a law of toxicology, but this rule is just one special case of a more general relationship c×tm=K, where the exponent m is quite variable. For inhaled toxicants m generally has a value between 0 and 1, whereas for carcinogens m is usually between 1 and 5. The absence of a universal value for m, or one that is generally applicable to different classes of toxicants, makes it not yet possible to develop a Haber-type rule with which to extrapolate successfully between exposure scenarios. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 101 van 222 gevonden artikelen
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