|
| << previous | next >> |
Journal description
All volumes of the corresponding journal
All issues of the corresponding volume
All articles of the corresponding issues
Details for article 164 of 262 found articles
| Title: |
Manufacturing Drug Loaded Chitosan Microspheres by Spray Drying: Development, Characterization, and Potential Use in Dentistry |
| Author: |
Braga, Glaucia K. Oliveira, Wanderley P. |
| Appeared in: |
Drying technology |
| Paging: | Volume 25 (2007) nr. 2 pages 303-310 |
| Year: |
2007-02 |
| Contents: |
The aim of this work was to determine specifications for spray-drying manufacturing of sustained-release drug-loaded microparticles with potential application in dentistry. Chitosan was used as the microencapsulation polymer and ketoprofen as the model drug. A 1:1 chitosan/ketoprofen suspension was spray-dried under different operating conditions. The size distribution, morphology, total drug load, and release profile of the powders were characterized. In vitro release studies were performed with the powder samples entrapped in cellulose dialysis tubes. The microparticles produced had a narrow size distribution (mean diameter ranging from 2.11 to 3.27 µm), good sphericity, and a smooth surface. In vitro release studies showed a linear drug dissolution behavior. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 164 of 262 found articles
| << previous | next >> |