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Details van artikel 9 van 18 gevonden artikelen
| Titel: |
ON-LINE OPTIMAL FEED OF SUBSTRATE DURING FED-BATCH CULTURE OF CELL MASS |
| Auteur: |
Huang, Hsiao-Ping Chang, Ling-Ling Chao, Yung-Cheng Huang, Shih-Yow |
| Verschenen in: |
Chemical engineering communications |
| Paginering: | Jaargang 68 (1988) nr. 1 pagina's 221-236 |
| Jaar: |
1988-06-01 |
| Inhoud: |
In the cultivation of cell mass, a mathematical model for the specific growth rate of the cells can be used to design a strategy for the optimal feed of substrate to the culture. In this paper, a model of specific growth rate valid at both low and high cell concentration is developed for Candida utilis and Candida brassicae. An on-line control algorithm is then proposed to determine the optimal substrate concentration for the production of cell mass in fed-batch culture. An on-line estimation scheme using the sensitivity method is also included for cases in which the cell mass can not be measured. Simulation results demonstrate that the proposed method can minimize the production time of fed-batch culture. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 9 van 18 gevonden artikelen
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