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| Titel: |
STUDY OF THE CLOUD POINT OF NORTRIPTYLINE HYDROCHLORIDE: EFFECT OF ADDITIVES |
| Auteur: |
Al-Ahmadi, Mohammed D. A. Naqvi, Andleeb Z. Akram, Mohd. |
| Verschenen in: |
Chemical engineering communications |
| Paginering: | Jaargang 195 (2008) nr. 8 pagina's 948-957 |
| Jaar: |
2008-08 |
| Inhoud: |
The work focuses on the clouding and dye solubilization phenomena in an amphiphilic drug, nortriptyline hydrochloride (NOT), which is a tricyclic antidepressant. A 30 mM drug solution prepared in 10 mM sodium phosphate buffer (pH: 7.07) showed CP at 45°C, which was found to decrease with the addition of long-chain alcohols and cyclohexanol but remained almost constant with short-chain alcohols. The behavior is explained on the basis of their nature: short-chain alcohols are water soluble and partition very little in micelles, whereas long-chain alcohols are hydrophobic and solubilize in drug aggregates. Diols decreased the CP. Addition of cationic surfactants increased the CP, whereas sugars caused a decrease. Dye solubilization results indicate micellar growth with fixed concentrations of surfactants. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 8 van 11 gevonden artikelen
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