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| Titel: |
SENSITIVITY OF RECOMBINANT FERMENTATION WITH RUN-AWAY PLASMIDS: A STRUCTURED ANALYSIS OF THE EFFECT OF DILUTION RATE |
| Auteur: |
Patnaik, P. R. |
| Verschenen in: |
Chemical engineering communications |
| Paginering: | Jaargang 131 (1995) nr. 1 pagina's 125-140 |
| Jaar: |
1995-01-01 |
| Inhoud: |
A recently validated four-compartment model is used to describe intra-cellular dynamics during fermentations with recombinant microorganisms containing temperature-sensitive (run-away) plasmids. The time-dependent sensitivities with respect to the dilution rate have been computed for normal and run-away replication. During normal replication the cells are most sensitive in the early stage of fermentation, and the intra-cellular compartment containing RNA and ribosomes is more sensitive than the other three lumped components. This is explained through a buffering effect. During run-away replication the sensitives are either constant or increase slowly with time, and there is a shift in the relative sensitivities of the intra-cellular components. All sensitivities except that of the substrate increase as the dilution rate increases. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 13 van 13 gevonden artikelen
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