Effects of melatonin on plasma levels of TNF-α, IL-1 and IL-6 in mice after lipopolysaccharide administration
Titel:
Effects of melatonin on plasma levels of TNF-α, IL-1 and IL-6 in mice after lipopolysaccharide administration
Auteur:
Bitzer-Quintero, Oscar K. Ortiz, Genaro G. Ruiz-Rizo, Leonel Torres-Mendoza, Blanca M. Vazquez-Valls, Eduardo Rodriguez-Perez, Miguel
Verschenen in:
Biological rhythm research
Paginering:
Jaargang 36 (2005) nr. 1-2 pagina's 159-168
Jaar:
2005-02
Inhoud:
Bidirectional dependence exists between the immune and neuroendocrine systems, with common chemical messengers, such as melatonin (MLT), having immunoregulatory functions in some mechanisms of endotoxic shock. We used 10 - 12-week-old female Balb/c mice, with an average weight of 22 - 24 g, maintained under a 12 h light - dark cycle. The LD100 of lipopolysaccharide (LPS) was determined to be 10 mg/kg (ip.) from a dose - response curve. Pretreatment with MLT (10 mg/kg ip.) increased survival by 60%, decreased plasma TNF-αε and increased IL-1. No significant changes were observed in levels of plasma IL-6.