|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 3 van 11 gevonden artikelen
| Titel: |
Diurnal Variation in the Protective Effect of Melatonin Against Gastric Injury Caused by Ischemia-Reperfusion |
| Auteur: |
Cabeza, Juan de la Lastra, Catalina Alarcon Martin, Maria Jose Herrerias, Juan Manuel Motilva, Virginia |
| Verschenen in: |
Biological rhythm research |
| Paginering: | Jaargang 33 (2002) nr. 3 pagina's 319-332 |
| Jaar: |
2002-07 |
| Inhoud: |
This study determined the diurnal variation of protective effects of melatonin (5, 10 and 20 mg/Kg, i.p.) against gastric damage caused by ischemia-reperfusion. Melatonin was given in the morning (9.00 a.m.), then late afternoon (18.00 p.m.). In both cases, gastric injury was induced 30 min after melatonin administration. The hormone administration clearly diminished the number and severity of ulcers in animals treated late afternoon (p < 0.01 and p < 0.001). No protection was detected in animals treated with melatonin in the morning. The protective action was accompanied by a significant reduction in lipid peroxides (nmol TBA/mg protein, p < 0.05) in gastric mucosa which normally increase after ischemia/reperfusion. In animals treated early evening, with protective doses of melatonin, an increase in the activities of enzymes glutathion peroxidase (GSH-px) and superoxide dismutase (SOD) in gastric mucosa (p < 0.05) was observed after the damage period when untreated animals were compared. In the morning hormone administration, however, no variations were observed in any parameters connected to the production of oxygen free radicals. The possible relationship among these variations suggests a cause-effect association between efficacy of exogenously administered melatonin protecting gastric mucosa integrity and changes associated with certain endogenous biorhythms. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 11 gevonden artikelen
| << vorige | volgende >> |