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| Titel: |
Non-sympathetic Nerve Regulation of Daily Rhythms of Serine Dehydratase, D Site-binding Protein, and HMG-CoA Reductase mRNA Levels in Rat Liver |
| Auteur: |
Ansai, Y. Sakamoto, T. Ogawa, H. |
| Verschenen in: |
Biological rhythm research |
| Paginering: | Jaargang 28 (1997) nr. 2 pagina's 185-197 |
| Jaar: |
1997-05 |
| Inhoud: |
Rat liver serine dehydratase, D site-binding protein, HMG-CoA reductase mRNA levels are known to exhibit daily rhythms which are affected by lesions of the suprachiasmatic nuclei (Ogawa and Ansai (1995) Arch. Biochem. Biophys., 316: 844-850) but not by adrenalectomy (Ansai, Y. and Ogawa, H. (1996) Biol. Rhythm Res., 27: 175-184). Autonomic nerves have been reported to be important in some metabolic processes in the liver, but little is known about the role of innervation in the generation of these rhythms. To this end, rat sympathetic hepatic nerves were destroyed by surgical and chemical procedures, and after four days the animals were killed at 6-hour intervals. Concentrations of noradrenaline, a major catecholamine in the liver, decreased to below 5% of control levels, indicating the completeness of denervation. However, the above three mRNA levels at each time point were not substantially influenced by this treatment. These findings suggest that the daily rhythms of serine dehydratase, D site-binding protein, and HMG-CoA reductase mRNA levels are not under sympathetic nervous control. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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