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| Titel: | |
| Auteur: | |
| Verschenen in: |
Analytical letters |
| Paginering: | Jaargang 40 (2007) nr. 18 pagina's 3392-3404 |
| Jaar: |
2007-12 |
| Inhoud: |
Clomipramine, an important tricylic antidepressant drug with low redox activity, was effectively electrocatalyzed on poly-aminobenzene sulfonic acid/Pt nano-clusters modified glassy carbon electrode (i.e., poly-ABSA/Pt/GCE) and generated a sensitive anodic peak at about 0.80 V in pH 8.1 PBS. ABSA was electropolymerized on the surface of GCE modified with Pt nano-clusters. Pt nanoparticles provide a 3 D and conductive structure for the polymer immobilization. The resulting sensor exhibited a considerable enhancement in voltammetric response characteristics: extending the linear range and lowering the detection limit. The anodic peak current of clomipramine was linear with its concentration over two concentration intervals, viz., 1.0×10-7∼4.0×10-6 M and 4.0×10-6∼4.0×10-5 M, with the detection limit of 1.0×10-9 M (S/N=3). This method was successfully applied to the determination of clomipramine in drug tablets and proved to be reliable compared with UV. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 12 gevonden artikelen
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