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| Titel: | |
| Auteur: | |
| Verschenen in: |
Analytical letters |
| Paginering: | Jaargang 32 (1999) nr. 7 pagina's 1421-1434 |
| Jaar: |
1999 |
| Inhoud: |
Two simple, rapid, sensitive and accurate methods (A and B) for the microdetermination of melatonin in pure form and in pharmaceutical formulations are developed. Method A is based on the formation of tris(o-phenanthroline)iron(II) complex (ferroin) upon reaction of melatonin with an iron(III)-o-phenanthroline mixture in sodium acetate-acetic acid buffer media. The ferroin complex is colorimetrically measured at λmax 510 nm against reagent blank. Method B is based on the reduction of Fe (III) by the drug which forms a colored complex (λmax 522 nm) with 2,2-bipyridyl. Optimizations of the experimental conditions are described. Beer's law is obeyed in the concentration range 0.4 - 6.4 μg ml-1 for A and 0.4 - 7.4 μg ml-1 for B, respectively. The developed methods are applied successfully for the determination of melatonin in pure form and in melatonin tablets without any interference from common excipients. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 1 van 15 gevonden artikelen
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